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Module 7: Head Injuries

Segment 4: Diffuse Brain Injuries

References labeled PEDS contain a pediatric element or primary focus.

Topic: Diffuse axonal injury

Topic: Delayed, chronic, & diffuse TBIs

Topic: Ischemic/hypoxic brain injuries

  • Alnaami I, Algahtany M, Mansour OY. Effectiveness and safety of endovascular therapy in patients with traumatic vertebral artery injury: A systematic review and meta-analysis. Injury. 2026;57(4):113111. doi: 10.1016/j.injury.2026.113111 https://pubmed.ncbi.nlm.nih.gov/41722263/.
  • Biffl WL, Moore EE, Kansagra AP, et al. Diagnosis and management of blunt cerebrovascular injuries: What you need to know. J Trauma Acute Care Surg. 2025;98(1):1-10. doi: 10.1097/ta.0000000000004439 https://pubmed.ncbi.nlm.nih.gov/39093622/.
  • Blair KJ, Hawley KL, Burlew CC. Management of carotid artery injuries: What you need to know. J Trauma Acute Care Surg. 2026;doi: 10.1097/ta.0000000000005122 https://pubmed.ncbi.nlm.nih.gov/42473982/.
  • Furtmann A, Lopez-Schultz S, Howk A, et al. Blunt cerebrovascular injury after ground-level falls: Yield of CT angiography and relevance of the expanded Denver criteria. J Trauma Acute Care Surg. 2026;doi: 10.1097/ta.0000000000005087 https://pubmed.ncbi.nlm.nih.gov/42268658/.
  • Gaspich JP, Solomon AL, Nordan TA, et al. Selective screening falls short: A review of universal screening for blunt cerebrovascular injury. Injury. 2026;57(6):113288. doi: 10.1016/j.injury.2026.113288 https://pubmed.ncbi.nlm.nih.gov/41997097/.
  • Hodžić I, Doelkahar B, Horn J, et al. A continuous convolutional neural network: very early EEG most predictive for poor neurological outcome in postanoxic coma. Resuscitation. 2026;219:110943. doi: 10.1016/j.resuscitation.2025.110943 https://pubmed.ncbi.nlm.nih.gov/41453650/.
  • Kim DY, Biffl W, Bokhari F, et al. Evaluation and management of blunt cerebrovascular injury: A practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2020;88(6):875-887. doi: 10.1097/ta.0000000000002668 https://pubmed.ncbi.nlm.nih.gov/32176167/.
  • Kobayashi L, Perkins L, Johnston W, et al. American Association for the Surgery of Trauma–World Society of Emergency Surgery guidelines on the diagnosis and management of cervical vascular injuries. J Trauma Acute Care Surg. 2026;100(3):509-519. doi: 10.1097/ta.0000000000004823 https://pubmed.ncbi.nlm.nih.gov/41533003/.
  • Leichtle SW, Banerjee D, Schrader R, et al. Blunt cerebrovascular injury - the case for universal screening. J Trauma Acute Care Surg. 2020;doi: 10.1097/ta.0000000000002824 https://pubmed.ncbi.nlm.nih.gov/32520898/.
  • Leng S, Li W, Cai Y, et al. The endovascular treatment strategies of cerebrovascular injuries in traumatic brain injury. Chin J Traumatol. 2025;doi: 10.1016/j.cjtee.2025.01.001 https://www.sciencedirect.com/science/article/pii/S1008127525000033.
  • Li A, Durr K, Fernando SM, et al. Rates of healing and timing of repeat imaging after blunt cerebrovascular injury: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2025;99(4):643-649. doi: 10.1097/ta.0000000000004748 https://pubmed.ncbi.nlm.nih.gov/40839786/.
  • Lim HO, Boremski P, Locklear T, et al. Evaluating blunt cerebrovascular injury screening in high-energy trauma patients: A rural trauma center study. J Surg Res. 2026;322:215-221. doi: 10.1016/j.jss.2026.03.050 https://pubmed.ncbi.nlm.nih.gov/41990636/.
  • Masch JL, Austin JR, Jaffray P, et al. Trust, but verify: the importance of additional imaging after BCVI screening. World J Emerg Surg. 2026;doi: 10.1186/s13017-026-00694-y https://pubmed.ncbi.nlm.nih.gov/41937190/.
  • Nekooei N, Bent C, Brabender D, et al. Long-Term Outcomes of Traumatic Neck Vascular Injury Repairs: A Prospective Observational Vascular Injury Treatment Registry Analysis. J Surg Res. 2026;325:394-403. doi: 10.1016/j.jss.2026.05.054 https://pubmed.ncbi.nlm.nih.gov/42341611/.
  • Nunes N, Nasef H, Baum S, et al. Risk factors and clinical outcomes among adult patients with isolated blunt cerebrovascular injuries: A national analysis. J Trauma Nurs. 2025;doi: 10.1097/jtn.0000000000000887 https://pubmed.ncbi.nlm.nih.gov/41092081/.
  • Russo RM, Davidson AJ, Alam HB, et al. Blunt cerebrovascular injuries: Outcomes from the American Association for the Surgery of Trauma PROspective Observational Vascular Injury Treatment (PROOVIT) multicenter registry. J Trauma Acute Care Surg. 2021;90(6):987-995. doi: 10.1097/ta.0000000000003127 https://pubmed.ncbi.nlm.nih.gov/34016922/.
  • Rutman AM, Vranic JE, Mossa-Basha M. Imaging and management of blunt cerebrovascular injury. Radiographics. 2018;38(2):542-563. doi: 10.1148/rg.2018170140 https://pubmed.ncbi.nlm.nih.gov/29528828/.
  • Saitta L, Resaz M, Robba C, et al. Neuroimaging for neurovascular complications of traumatic brain injury. Crit Care. 2025;29(1):362. doi: 10.1186/s13054-025-05586-2 https://pubmed.ncbi.nlm.nih.gov/40826095/.
  • Schauer SG, April MD, Fisher AD, et al. Blunt cerebrovascular injury in trauma—Fixed or modifiable risk factor for stroke? J Surg Res. 2025;317:167-172. doi: 10.1016/j.jss.2025.11.029 https://pubmed.ncbi.nlm.nih.gov/41380224/.
  • Serban NL, Ungureanu G, Florian IS, et al. Cerebral vascular disturbances following traumatic brain injury: Pathophysiology, diagnosis, and therapeutic perspectives—A narrative review. Life (Basel). 2025;15(9) doi: 10.3390/life15091470 https://pubmed.ncbi.nlm.nih.gov/41010412/.
  • Stanislaus V, Mitra B, Zhang WW, et al. The incidence and characteristics of clinically relevant blunt cerebrovascular injury at an adult level 1 trauma centre: A retrospective cohort study. Trauma. 2024;26(4):289-296. doi: 10.1177/14604086231177124 https://journals.sagepub.com/doi/abs/10.1177/14604086231177124.
  • Stanislaus V, Zhang WW, Chen Z, et al. Inpatient stroke outcomes in patients with blunt cerebrovascular injuries according to risk factors and treatment. Trauma. 2025;0(0):14604086251333569. doi: 10.1177/14604086251333569 https://journals.sagepub.com/doi/abs/10.1177/14604086251333569.
  • Teasdale B, Owolo E, Padmanaban V, et al. Traumatic vertebral artery injury: Diagnosis, natural history, and key considerations for management. J Clin Med. 2025;14(9) doi: 10.3390/jcm14093159 https://pubmed.ncbi.nlm.nih.gov/40364191/.