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Module 6: Musculoskeletal Injuries

Segment 6: Kidney Injury

References labeled PEDS contain a pediatric element or primary focus.

Topic: Kidney injury in the trauma patient

  • Booke H, von Groote T, Zarbock A. Ten tips on how to reduce iatrogenic acute kidney injury. Clin Kidney J. 2025;18(2):sfae412. doi: 10.1093/ckj/sfae412 https://pubmed.ncbi.nlm.nih.gov/39950155/.
  • Fregoso G, Ansari A, Littlejohn J, et al. Management of acute kidney injury in critical illness. Best Pract Res Clin Anaesthesiol. 2026;40(1):65-73. doi: 10.1016/j.bpa.2026.06.002 https://pubmed.ncbi.nlm.nih.gov/42552024/.
  • Gómez H, Chen X, Minturn JS, et al. Persistent severe acute kidney injury is a major modifiable determinant of outcome during critical illness. Intensive Care Med. 2025;doi: 10.1007/s00134-025-07821-4 https://pubmed.ncbi.nlm.nih.gov/39966171/.
  • Hashimoto H, Yamada H, Murata M, et al. Diuretics for preventing and treating acute kidney injury. Cochrane Database Syst Rev. 2025;1(1):Cd014937. doi: 10.1002/14651858.CD014937.pub2 https://pubmed.ncbi.nlm.nih.gov/39878152/.
  • Lim F, Li A. Acute kidney injury: A nursing challenge. Am Nurse J. 2023;18(6):6-12. doi:  https://www.myamericannurse.com/wp-content/uploads/2023/05/an6-CE-Kidney-517a.pdf.
  • Mercado MG, Smith DK, Guard EL. Acute kidney injury: Diagnosis and management. Am Fam Physician. 2019;100(11):687-694. doi:  https://pubmed.ncbi.nlm.nih.gov/31790176/.
  • Noel S, Kapoor R, Rabb H. New approaches to acute kidney injury. Clin Kidney J. 2024;17(Suppl 2):65-81. doi: 10.1093/ckj/sfae265 https://pubmed.ncbi.nlm.nih.gov/39583139/.
  • Ostermann M, Legrand M, Meersch M, et al. Biomarkers in acute kidney injury. Ann Intensive Care. 2024;14(1):145. doi: 10.1186/s13613-024-01360-9 https://pubmed.ncbi.nlm.nih.gov/39279017/.
  • Patel PP, Egodage T. Failing kidneys: renal replacement therapies in the ICU. Trauma Surg Acute Care Open. 2024;9(Suppl 2):e001381. doi: 10.1136/tsaco-2024-001381 https://pubmed.ncbi.nlm.nih.gov/38646026/.
  • Perazella MA. Drug-induced acute kidney injury: diverse mechanisms of tubular injury. Curr Opin Crit Care. 2019;25(6):550-557. doi: 10.1097/mcc.0000000000000653 https://pubmed.ncbi.nlm.nih.gov/31483318/.
  • Qi J, Wu W, Wang J, et al. Selection of timing of continuous renal replacement therapy in patients with acute kidney injury: A meta-analysis of randomized controlled trials. PLoS One. 2025;20(3):e0320351. doi: 10.1371/journal.pone.0320351 https://pubmed.ncbi.nlm.nih.gov/40131982/.
  • Rhee H. Dialysis decision in critically ill patients in intensive care unit. Acute Crit Care. 2025;40(1):1-9. doi: 10.4266/acc.004896 https://pubmed.ncbi.nlm.nih.gov/40074521/.
  • Rroji M, Kasa M, Spahia N, et al. Kidneys on the frontline: Nephrologists tackling the wilds of acute kidney injury in trauma patients—From pathophysiology to early biomarkers. Diagnostics (Basel). 2025;15(19) doi: 10.3390/diagnostics15192438 https://pubmed.ncbi.nlm.nih.gov/41095657/.
  • Sertaridou E, Alexopoulou C, Papaioannou V. Bimodal distribution of trauma-related acute kidney injury (TrAKI): A clinical review. J Crit Care Med (Targu Mures). 2026;12(1):5-19. doi: 10.2478/jccm-2026-0009 https://pubmed.ncbi.nlm.nih.gov/41704331/.
  • Shi K, Jiang W, Song L, et al. Persistent acute kidney injury biomarkers: A systematic review and meta-analysis. Clin Chim Acta. 2025;564:119907. doi: 10.1016/j.cca.2024.119907 https://pubmed.ncbi.nlm.nih.gov/39127297/.
  • Teixeira JP, Hiremath S, Kabli AO, et al. Continuous kidney replacement therapies: Core curriculum 2025. Am J Kidney Dis. 2025;doi: 10.1053/j.ajkd.2024.09.015 https://pubmed.ncbi.nlm.nih.gov/40072400/.
  • Turgut F, Awad AS, Abdel-Rahman EM. Acute kidney injury: Medical causes and pathogenesis. J Clin Med. 2023;12(1) doi: 10.3390/jcm12010375 https://pubmed.ncbi.nlm.nih.gov/36615175/.
  • Villegas CV, Gorman E, Liu FM, et al. Acute kidney injury in the acute care surgery patient: What you need to know. J Trauma Acute Care Surg. 2024;97(6):839-848. doi: 10.1097/ta.0000000000004401 https://pubmed.ncbi.nlm.nih.gov/39238092/.
  • Zarbock A, Ostermann M, Forni L, et al. A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial. Lancet. 2025;406(10521):2782-2791. doi: 10.1016/s0140-6736(25)01717-9 https://pubmed.ncbi.nlm.nih.gov/41242333/.